Plants employ cell-surface receptors to perceive non- or altered-self, including the integrity of their cell wall. Here we identify a specific ligand–receptor module responsive to cell wall damage that potentiates immunity in Arabidopsis. Disruption of cell wall integrity by inhibition of cellulose biosynthesis promotes pattern-triggered immunity transcriptionally in a manner dependent on the receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2). Notably, while MIK2 can perceive peptides of the large SERINE RICH ENDOGENOUS PEPTIDE family, a single member of this family, SCOOP18, is transcriptionally induced upon cell wall damage and is required for subsequent responses such as lignification and immunity potentiation. Collectively, our results identify the SCOOP18–MIK2 ligand–receptor module as an important central hub, connecting plant cell wall integrity sensing with immunity.

植物利用细胞表面受体来感知非自我或改变自我，包括其细胞壁的完整性。在这里，我们确定了一种对细胞壁损伤有反应的特异性配体-受体模块，可增强拟南芥的免疫力。通过抑制纤维素生物合成破坏细胞壁完整性，以依赖于受体激酶 MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 （MIK2） 的方式促进模式触发的免疫。值得注意的是，虽然 MIK2 可以感知大型富含丝氨酸的内源性肽家族的肽，但该家族的单个成员 SCOOP18 在细胞壁损伤时被转录诱导，并且是木质化和免疫增强等后续反应所必需的。总的来说，我们的结果将 SCOOP18-MIK2 配体-受体模块确定为重要的中心枢纽，将植物细胞壁完整性传感与免疫联系起来。