This European Academy of Allergy and Clinical Immunology (EAACI) guideline provides recommendations for the management of IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Following the confirmation of IgE‐mediated food allergy diagnosis, allergen avoidance and dietary advice (with support of a specialised dietitian, if possible) together with the provision of a written treatment plan, education on the recognition of allergic symptoms and prescription of medication including adrenaline using an auto‐injector are essential. Patients with significant anxiety and requirement for coping strategies may benefit from support from a clinical psychologist. As immunomodulatory interventions, omalizumab is suggested for treatment of IgE‐mediated food allergy in children from the age of 1 and adults; and oral allergen‐specific immunotherapy is recommended for children and adolescents with peanut allergy and suggested for milk and egg allergies (generally after 4 years of age for milk and egg). Sublingual and epicutaneous immunotherapy are suggested for peanut allergy but are not yet available at the point of care. Future research into disease modifying treatments for IgE‐mediated food allergy are highly needed, with standardised and patient‐focused protocols and outcomes.

中文翻译：

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EAACI IgE 介导的食物过敏管理指南


该欧洲过敏和临床免疫学会 （European Academy of Allergy and Clinical Immunology， EAACI） 指南为管理 IgE 介导的食物过敏提供了建议，并使用建议分级、评估、开发和评估 （GRADE） 方法制定。在确认 IgE 介导的食物过敏诊断、避免过敏原和饮食建议（如果可能，在专业营养师的支持下）以及提供书面治疗计划后，必须对识别过敏症状和开具药物（包括肾上腺素）进行教育，使用自动注射器。有明显焦虑和需要应对策略的患者可能会从临床心理学家的支持中受益。作为免疫调节干预措施，奥马珠单抗被建议用于治疗 1 岁以上儿童和成人的 IgE 介导的食物过敏;建议对花生过敏的儿童和青少年进行口服变应原特异性免疫治疗，并建议对牛奶和鸡蛋过敏（通常在 4 岁以后对牛奶和鸡蛋过敏）。建议对花生过敏进行舌下和表皮免疫治疗，但目前尚无护理点提供的免疫疗法。未来非常需要对 IgE 介导的食物过敏的疾病修饰治疗进行研究，并制定标准化和以患者为中心的方案和结果。