Brain imaging studies have reported that the neural deficits of congenital amusia in non-tonal language speakers are mainly in the connectivity between the auditory cortex and the inferior frontal gyrus (IFG) in the right hemisphere. However, the relationship between the functional connectivity (FC) in these regions and the music perception ability of amusia in tonal language speakers remains unclear. In this study, we investigated the FC characteristics of amusia in Mandarin speakers in resting-state functional magnetic resonance imaging data by voxel-wise connectivity analyses with seeds in left and right Heschl's gyri (HG) and region of interest (ROI)-to-ROI connectivity analyses. Our findings indicate increased connectivity between right HG and bilateral posterior superior temporal gyrus, as determined by voxel-wise connectivity analyses in amusia. Conversely, reduced connectivity was observed between bilateral HG and bilateral IFG (orbital part) as assessed through ROI-to-ROI connectivity analyses in amusia when compared to controls. Moreover, the music perception scores of amusia in Mandarin speakers were associated with diminished connectivity between the left HG and the right IFG. This study furnishes direct evidence for the link between music perception deficits and the aberrant frontotemporal connectivity of congenital amusia in tonal language speakers in resting state.

中文翻译：

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先天性失眠患者听觉皮层静息态连接性改变：普通话使用者的功能磁共振成像研究


脑成像研究报告称，非声调语言使用者先天性失眠的神经缺陷主要在于听觉皮层与右半球额下回 （IFG） 之间的连接。然而，这些区域的功能连接 （FC） 与声调语言使用者 amusia 的音乐感知能力之间的关系尚不清楚。在这项研究中，我们通过体素连接分析，在左右 Heschl 回 （HG） 和感兴趣区域 （ROI） 到 ROI 连接分析中研究了静息态功能磁共振成像数据中普通话使用者 amusia 的 FC 特征。我们的研究结果表明，右 HG 和双侧后颞上回之间的连接性增加，这是由 amusia 中的体素连接分析确定的。相反，与对照组相比，通过在 amusia 中通过 ROI 到 ROI 连接分析评估，观察到双侧 HG 和双侧 IFG（轨道部分）之间的连接性降低。此外，普通话使用者中 amusia 的音乐感知分数与左侧 HG 和右侧 IFG 之间的连接性减弱有关。这项研究为音乐感知缺陷与静息状态下声调语言使用者先天性 amusia 异常额颞连接之间的联系提供了直接证据。