Hydroxyapatite is commonly used as a biomaterial in the orthopedic and dental fields. This natural component is considered to be safe and triggers no immune response. Hydroxyapatite nanoparticles (HANPs) have been developed and used in different bone-related therapies and could be good candidates for other purposes, such as drug delivery. However, concerns about their safety have arisen with studies reporting nephrotoxicity in rats. A study in Scientific Reports confirms the neurotoxic effects of HANPs in adult male Wistar rats. However, the team found that co-supplementation with chitosan and curcumin nanoparticles could improve the neural damage caused by HANPs, showing potential protective capabilities by decreasing neuroinflammation, oxidative stress and DNA damage. These results could help improve the safety of HANPs, opening the avenue for further use of these nanoparticles in future therapies.

Original reference: Eldeeb, G.M. et al. Sci. Rep. 14, 21009 (2024)

羟基磷灰石通常用作骨科和牙科领域的生物材料。这种天然成分被认为是安全的，不会触发免疫反应。羟基磷灰石纳米颗粒 （HANP） 已被开发并用于不同的骨骼相关疗法，可能是其他目的的良好候选者，例如药物输送。然而，随着研究报告大鼠的肾毒性，人们对它们的安全性产生了担忧。Scientific Reports 上的一项研究证实了 HANP 对成年雄性 Wistar 大鼠的神经毒性作用。然而，研究小组发现，壳聚糖和姜黄素纳米颗粒的共同补充可以改善 HANP 引起的神经损伤，通过减少神经炎症、氧化应激和 DNA 损伤来显示出潜在的保护能力。这些结果可能有助于提高 HANP 的安全性，为这些纳米颗粒在未来疗法中的进一步使用开辟了道路。

原始参考资料：Eldeeb， G.M. 等人 Sci. Rep.14， 21009 （2024）