Positive, negative and disorganised psychotic symptom dimensions are associated with clinical and developmental variables, but differing definitions complicate interpretation. Additionally, some variables have had little investigation.

To investigate associations of psychotic symptom dimensions with clinical and developmental variables, and familial aggregation of symptom dimensions, in multiple samples employing the same definitions.

We investigated associations between lifetime symptom dimensions and clinical and developmental variables in two twin and two general psychosis samples. Dimension symptom scores and most other variables were from the Operational Criteria Checklist. We used logistic regression in generalised linear mixed models for combined sample analysis (n = 875 probands). We also investigated correlations of dimensions within monozygotic (MZ) twin pairs concordant for psychosis (n = 96 pairs).

Higher symptom scores on all three dimensions were associated with poor premorbid social adjustment, never marrying/cohabiting and earlier age at onset, and with a chronic course, most strongly for the negative dimension. The positive dimension was also associated with Black and minority ethnicity and lifetime cannabis use; the negative dimension with male gender; and the disorganised dimension with gradual onset, lower premorbid IQ and substantial within twin-pair correlation. In secondary analysis, disorganised symptoms in MZ twin probands were associated with lower premorbid IQ in their co-twins.

These results confirm associations that dimensions share in common and strengthen the evidence for distinct associations of co-occurring positive symptoms with ethnic minority status, negative symptoms with male gender and disorganised symptoms with substantial familial influences, which may overlap with influences on premorbid IQ.

阳性、阴性和杂乱无章的精神病症状维度与临床和发展变量相关，但不同的定义使解释复杂化。此外，一些变量的研究很少。

在采用相同定义的多个样本中，研究精神病症状维度与临床和发展变量的关联，以及症状维度的家族聚合。

我们调查了两个双胞胎和两个一般精神病样本的终生症状维度与临床和发展变量之间的关联。维度症状评分和大多数其他变量来自操作标准清单。我们在广义线性混合模型中使用 logistic 回归进行组合样本分析 （n = 875 名先证者）。我们还调查了与精神病一致的同卵 （MZ） 双胞胎对 （n = 96 对） 内维度的相关性。

所有三个维度的较高症状评分与病前社会适应不良、从未结婚/同居和发病年龄较早以及慢性病程相关，在阴性维度中最为强烈。积极维度还与黑人和少数族裔以及终生使用大麻有关;男性的负维度;以及逐渐起病的杂乱无章的维度，发病前 IQ 较低，并且在双对相关性中很大。在二次分析中，MZ 双胞胎先证者的症状杂乱与他们的同胞双胞胎的病前智商较低相关。

这些结果证实了维度共有的关联，并加强了同时发生的阳性症状与少数民族地位、阴性症状与男性以及杂乱无章的症状与重大家族影响的明显关联的证据，这可能与对病前智商的影响重叠。