OBJECTIVE This study aimed to investigate the association between age at natural menopause and incidence of asthma among postmenopausal Canadian women. METHODS Women between the ages of 45-85 yr were followed for a 10-yr period. Analysis was restricted to naturally postmenopausal women who are nonsmokers and did not have asthma prior to menopause. Age at natural menopause was examined using the following categories: 40-44, 45-49, 50-54 (reference), and ≥55. Survival analysis was utilized to determine time to onset of asthma. Multivariable Cox regression analysis was performed to assess the relationship between age at natural menopause and asthma after adjusting for covariates. RESULTS The multivariable Cox regression analysis showed a 30% decreased risk of asthma in women with age at natural menopause of 40-44 yr compared with age at natural menopause of 50-54 yr with a hazard ratio of 0.7 (95% confidence interval: 0.49-0.95). CONCLUSIONS Women with later ages at natural menopause may be at increased risk for asthma.

中文翻译：

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自然绝经年龄与绝经后妇女哮喘风险之间的关联 来自加拿大老龄化纵向研究。


目的 本研究旨在探讨加拿大绝经后妇女自然绝经年龄与哮喘发病率之间的相关性。方法 对 45-85 岁的女性进行了为期 10 年的随访。分析仅限于自然绝经后妇女，她们不吸烟且绝经前没有哮喘。使用以下类别检查自然绝经年龄：40-44、45-49、50-54（参考）和 ≥55。生存分析用于确定哮喘发作的时间。进行多变量 Cox 回归分析，以评估校正协变量后自然绝经年龄与哮喘之间的关系。结果多变量 Cox 回归分析显示，与自然绝经 50-54 岁相比，自然绝经 40-44 岁女性患哮喘的风险降低了 30%，风险比为 0.7（95% 置信区间：0.49-0.95）。结论 自然绝经年龄较晚的女性患哮喘的风险可能增加。