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A strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2024-10-28 , DOI: 10.1002/art.43044
Javier Martínez-López, Lourdes Ortiz-Fernandez, Elkyn Estupiñán-Moreno, Martin Kerick, Eduardo Andrés-León, Laura C. Terron-Camero, Elena Carnero-Montoro, Guillermo Barturen, Lorenzo Beretta, Isabel Almeida, , Marta E. Alarcón-Riquelme, Esteban Ballestar, Marialbert Acosta-Herrera, Javier Martín

Nongenetic factors influence systemic sclerosis (SSc) pathogenesis, underscoring epigenetics as a relevant contributor to the disease. We aimed to unravel DNA methylation abnormalities associated with SSc through an epigenome-wide association study.

中文翻译:


系统性硬化症表观遗传景观中的强失调髓系成分:整合的 DNA 甲基化组和转录组分析



非遗传因素影响系统性硬化症 (SSc) 的发病机制,强调表观遗传学是导致该疾病的相关因素。我们旨在通过表观基因组范围的关联研究来揭示与 SSc 相关的 DNA 甲基化异常。
更新日期:2024-10-28
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