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Genome-wide integrated DNA methylome and transcriptome analysis reveals a strong dysregulated myeloid component in the epigenetic landscape of Systemic Sclerosis
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2024-10-28 , DOI: 10.1002/art.43044
Javier Martínez-López, Lourdes Ortiz-Fernandez, Elkyn Estupiñán-Moreno, Martin Kerick, Eduardo Andrés-León, Laura C Terron-Camero, Elena Carnero-Montoro, Guillermo Barturen, Lorenzo Beretta, Isabel Almeida, , Marta E. Alarcón-Riquelme, Esteban Ballestar, Marialbert Acosta-Herrera, Javier Martín

Non-genetic factors influence Systemic Sclerosis (SSc) pathogenesis, underscoring epigenetics as a relevant contributor to the disease. We aimed to unravel DNA methylation abnormalities associated with SSc through an epigenome-wide association study (EWAS).

中文翻译:


全基因组整合 DNA 甲基化组和转录组分析揭示了系统性硬化症表观遗传景观中强烈的失调髓系成分



非遗传因素影响系统性硬化症 (SSc) 的发病机制,强调表观遗传学是导致该疾病的相关因素。我们旨在通过表观全基因组关联研究 (EWAS) 揭示与 SSc 相关的 DNA 甲基化异常。
更新日期:2024-10-30
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