Cardiovascular diseases (CVDs) are recognized as a significant threat to global health. The rapid, sensitive, and precise measurement of relevant biomarkers is essential for the timely diagnosis of CVDs. Molecularly imprinted polymers (MIPs), which act as artificial receptor recognition materials, have been extensively utilized in the detection of CVD biomarkers. Their widespread application is due to their cost-effectiveness, physical and chemical stability, straightforward preparation processes, and excellent compatibility with various sensor types. This review introduces the principles of MIP sensors in combination with electrochemical, optical, thermal transfer, and acoustic detection techniques for detecting CVD-related biomarkers. It then discusses methods developed over the past decade for detecting biomarkers of three major CVDs—coronary artery disease (CAD), acute myocardial infarction (AMI), and heart failure (HF)—using MIP sensors. Finally, the review summarizes the potential of MIP sensors in CVD biomarker detection and provides an outlook on future research directions.

中文翻译：

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用于心血管疾病生物标志物检测的分子印迹聚合物传感器


心血管疾病 （CVD） 被认为是对全球健康的重大威胁。快速、灵敏和精确地测量相关生物标志物对于及时诊断 CVD 至关重要。分子印迹聚合物 （MIP） 作为人工受体识别材料，已广泛用于 CVD 生物标志物的检测。它们的广泛应用是由于其成本效益、物理和化学稳定性、简单的制备工艺以及与各种传感器类型的出色兼容性。本文介绍了 MIP 传感器结合电化学、光学、热传递和声学检测技术检测 CVD 相关生物标志物的原理。然后，它讨论了过去十年开发的使用 MIP 传感器检测三种主要 CVD（冠状动脉疾病 （CAD）、急性心肌梗死 （AMI） 和心力衰竭 （HF））生物标志物的方法。最后，综述总结了 MIP 传感器在 CVD 生物标志物检测中的潜力，并对未来的研究方向进行了展望。