INTRODUCTIONWhile the influence of cross‐sectional β‐amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change‐on‐change between Aβ and cognition is less explored.METHODSA series of bivariate latent change score models (LCSM) examined the relationship between changes in 11C‐Pittsburgh Compound‐B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite‐5 (PACC‐5) while adjusting for covariates, including cross‐sectional medial temporal lobe (MTL) tau‐PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB‐PET and PACC‐5 data from the Harvard Aging Brain Study (HABS).RESULTSAβ accumulation was associated with subsequent cognitive decline beyond the effects of cross‐sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross‐sectional tau‐PET and cognitive intercept/slope.DISCUSSIONShort‐term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross‐sectional Aβ and MTL tau.Highlights Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau‐PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau.

中文翻译：

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淀粉样蛋白积累和认知能力下降之间的潜在变化


引言尽管横断面 β-淀粉样蛋白 （Aβ） 对认知纵向变化的影响已得到充分证实，但 Aβ 和认知之间的纵向变化较少被探索。方法一系列双变量潜在变化评分模型 （LCSM） 检查了 11C-匹兹堡化合物-B （PiB） 正电子发射断层扫描 （PET） 和临床前阿尔茨海默病认知复合-5 （PACC-5） 变化之间的关系，同时调整协变量，包括横截面内侧颞叶 （MTL） tau-PET 负担。我们从哈佛老龄化脑研究 （HABS） 中选择了 352 名临床正常的老年参与者，他们具有长达 9 年的 PiB-PET 和 PACC-5 数据。结果Aβ 积累与随后的认知能力下降相关，超出了横断面 Aβ 负荷的影响。在这个包括年龄、性别和载脂蛋白 ε4 （APOEε4） 状态等协变量的模型中，我们发现没有证据支持先前发表的横断面 tau-PET 与认知截距/斜率之间的关联。讨论短期 Aβ 变化与临床正常老年人的认知能力下降显著相关，并且可能使横断面 Aβ 和 MTL tau 的影响黯然失色。亮点 Aβ 积累与随后的认知能力下降有关。高 Aβ 负担并不是预示认知能力即将下降的唯一指标。与之前的工作相反，MTL tau-PET 和认知在我们的模型中没有关联。双变量潜伏 Aβ 和认知变化的模型可能会使 MTL tau 的影响黯然失色。