Deuterated hydroxyl acids and amino acids have been widely utilized in life science, biochemistry and drug development. Site‐selective and stereoselective synthesis of deuterated hydroxyl acids and amino acids remains a significant challenge. Here, we report the development of a robust whole‐cell‐based chemoenzymatic platform for the synthesis of deuterated hydroxyl acids and amino acids from off‐the‐shelf aldehydes in high yields with excellent selectivities and levels of deuteration. The platform delivers products with diverse scaffolds and deuteration patterns, as well as broad scopes with both aromatic and aliphatic side chains. The application of the platform was demonstrated by the concise synthesis of a deuterium‐containing antiparkinson's disease candidate. This platform provides a concrete foundation for accessing amino acid isotopologs for potential applications in research and drug discovery and development.

中文翻译：

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基于全细胞的化学酶合成位点选择性氘代 α-羟基酸和 α-氨基酸


氘代羟基酸和氨基酸已广泛应用于生命科学、生物化学和药物开发领域。氘代羟基酸和氨基酸的位点选择性和立体选择性合成仍然是一个重大挑战。在这里，我们报道了一种强大的基于全细胞的化学酶平台的开发，该平台用于从现成的醛中以高产率合成氘代羟基酸和氨基酸，具有出色的选择性和氘化水平。该平台提供具有多种支架和氘化模式的产品，以及具有芳香族和脂肪族侧链的广泛范围。该平台的应用通过简明合成含氘的抗帕金森病候选药物来证明。该平台为获取氨基酸同位素提供了坚实的基础，以用于研究和药物发现和开发的潜在应用。