Background Vigorous intermittent lifestyle physical activity (VILPA) refers to brief bouts of intense physical activity embedded into daily life. Objective To examine sex differences in the dose–response association of VILPA with major adverse cardiovascular events (MACE) and its subtypes. Methods Using multivariable-adjusted cubic splines, we examined the associations of daily VILPA duration with overall MACE and its subtypes (incident myocardial infarction, heart failure and stroke) among non-exercisers (individuals self-reporting no leisure-time exercise and no more than one recreational walk per week) in the UK Biobank. We also undertook analogous analyses for vigorous physical activity among exercisers (individuals self-reporting participation in leisure-time exercise and/or recreational walking more than once a week). Results Among 13 018 women and 9350 men, there were 331 and 488 all MACE, respectively, over a 7.9-year follow-up. In women, daily VILPA duration exhibited a near-linear dose–response association with all MACE, myocardial infarction and heart failure. In men, dose-reponse curves were less clear with less evidence of statistical signifigance. Compared with women with no VILPA, women’s median daily VILPA duration of 3.4 min was associated with hazard ratios (HRs; 95% confidence intervals) of 0.55 (0.41 to 0.75) for all MACE and 0.33 (0.18 to 0.59) for heart failure. Women’s minimum doses of 1.2–1.6 min of VILPA per day were associated with HRs of 0.70 (0.58 to 0.86) for all MACE, 0.67 (0.50 to 0.91) for myocardial infarction, and 0.60 (0.45 to 0.81) for heart failure. The equivalent analyses in UK Biobank’s accelerometry sub-study exercisers suggested no appreciable sex differences in dose–response. Conclusions Among non-exercising women, small amounts of VILPA were associated with a substantially lower risk of all MACE, myocardial infarction and heart failure. VILPA may be a promising physical activity target for cardiovascular disease prevention, particularly in women unable or not willing to engage in formal exercise. The data that support the findings of this study are available from the UK Biobank, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are, however, available from the authors upon reasonable request and with permission of the UK Biobank. ES and MA had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The statistical code used in the analyses of this manuscript is available upon request. The authors have archived the statistical code of multiple similar manuscripts, e.g. .

中文翻译：

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设备测量的剧烈间歇性生活方式体力活动 （VILPA） 和主要不良心血管事件：性别差异的证据


背景 剧烈的间歇性生活方式体育活动 （VILPA） 是指嵌入日常生活中的短暂剧烈体育活动。目的 探讨 VILPA 与主要不良心血管事件 （MACE） 及其亚型的剂量反应相关性的性别差异。方法使用多变量调整的三次样条，我们检查了英国生物银行中非锻炼者 （个体自我报告没有闲暇时间锻炼且每周不超过一次休闲散步） 每日 VILPA 持续时间与总体 MACE 及其亚型 （新发心肌梗死、心力衰竭和中风） 的关联。我们还对锻炼者的剧烈身体活动进行了类似的分析（个体自我报告每周参加闲暇时间锻炼和/或休闲步行超过一次）。结果 在 13 018 名女性和 9350 名男性中，分别有 331 名和 488 名全 MACE，随访 7.9 年。在女性中，每日 VILPA 持续时间与所有 MACE 、心肌梗死和心力衰竭表现出近线性的剂量反应关联。在男性中，剂量反应曲线不太清晰，统计学显着性的证据较少。与无 VILPA 的女性相比，女性每日 VILPA 持续时间中位数为 3.4 分钟，所有 MACE 的风险比 （HR;95% 置信区间） 为 0.55 （0.41 至 0.75），心力衰竭为 0.33 （0.18 至 0.59）。女性每天 1.2-1.6 分钟的 VILPA 最低剂量与所有 MACE 的 HR 为 0.70（0.58 至 0.86）、心肌梗死的 HR为 0.67（0.50 至 0.91）和心力衰竭的 HRs 为 0.60（0.45 至 0.81）相关。UK Biobank 的加速度测量子研究锻炼者中的等效分析表明剂量反应没有明显的性别差异。 结论 在不运动的女性中，少量 VILPA 与所有 MACE、心肌梗死和心力衰竭的风险显着降低相关。VILPA 可能是预防心血管疾病的一个有前途的身体活动目标，特别是对于不能或不愿进行正式锻炼的女性。支持本研究结果的数据可从英国生物样本库获得，但这些数据的可用性受到限制，这些数据是在当前研究的许可下使用的，因此不公开可用。但是，数据可在合理要求和英国生物样本库许可下从作者处获得。ES 和 MA 对研究中的所有数据具有完全访问权限，并负责数据的完整性和数据分析的准确性。本手稿分析中使用的统计代码可应要求提供。作者存档了多篇类似手稿的统计代码，例如.