Decreased periodontal ligament stem cells (PDLSCs) stemness is a key factor in age-related alveolar bone loss. Endoplasmic reticulum (ER) stress is closely related to age-related diseases and the mesenchymal stem cell (MSC) stemness. However, the role of ER stress in regulating the stemness of senescent PDLSCs and its potential mechanism remain unclear.

中文翻译：

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衰老的牙周韧带干细胞的干性受损是由早老素/内质网应力/ p53轴介导的


牙周韧带干细胞 （PDLSCs） 干性降低是与年龄相关的牙槽骨质流失的关键因素。内质网 （ER） 应激与年龄相关疾病和间充质干细胞 （MSC） 干性密切相关。然而，ER 应激在调节衰老 PDLSCs 干性中的作用及其潜在机制仍不清楚。