The protein p53, encoded by the most frequently mutated gene TP53 in human cancers, has diverse functions in tumor suppression. As a best known transcription factor, p53 can regulate various fundamental cellular responses, ranging from the cell-cycle arrest, DNA repair, senescence to the programmed cell death (PCD), which includes autophagy, apoptosis, ferroptosis, cuproptosis, pyroptosis and disulfidoptosis. Accumulating evidence has indicated that the tumor microenvironment (TME), N6-methyladenosine (m6A) modification and diverse PCD are important for the progression, proliferation and metastases of cancers.

中文翻译：

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p53 在癌症发展中的多重作用：肿瘤微环境的调节、m6A 修饰和多种细胞死亡机制


在人类癌症中，由最常突变的基因 TP53 编码的 p53 蛋白在肿瘤抑制中具有多种功能。作为最著名的转录因子，p53 可以调节各种基本的细胞反应，从细胞周期停滞、DNA 修复、衰老到程序性细胞死亡 （PCD），包括自噬、细胞凋亡、铁死亡、铜细胞凋亡、焦亡和双硫细胞亡。越来越多的证据表明，肿瘤微环境 （TME）、N6-甲基腺苷 （m6A） 修饰和多样化的 PCD 对癌症的进展、增殖和转移很重要。