Cell therapies, potent populations of cells used to treat disease and injury, can be strategically manufactured with biomaterial intervention to improve clinical translation. In this viewpoint, we discuss biomaterial design and integration into cell manufacturing steps to achieve three main goals: scale-up, phenotype control, and selection of potent cells. Material properties can be engineered to influence the cell–biomaterial interface and, therefore, impart desirable cell behavior such as growth, secretory activity, and differentiation. Future directions for the field should capitalize on the combinatorial design of biomaterial properties to yield highly specific and potent cell populations. Furthermore, future biomaterials could contribute to novel high-throughput cell separation technologies that can individually select the most therapeutically relevant cells within a produced batch.

中文翻译：

---

用于细胞制造的生物材料


细胞疗法是用于治疗疾病和损伤的强效细胞群，可以通过生物材料干预进行战略性制造，以改善临床转化。在这个观点中，我们讨论了生物材料设计和整合到细胞制造步骤中，以实现三个主要目标：放大、表型控制和有效细胞的选择。材料特性可以被设计成影响细胞-生物材料界面，从而赋予理想的细胞行为，如生长、分泌活性和分化。该领域的未来方向应利用生物材料特性的组合设计来产生高度特异性和有效的细胞群。此外，未来的生物材料可能有助于新型高通量细胞分离技术，该技术可以在生产的批次中单独选择最具治疗相关性的细胞。