Ion transport across biological membranes, facilitated by naturally occurring ion channels and pumps, plays a crucial role in biological processes. Gating is an important aspect of these systems, whereby transport is regulated by a range of external stimuli such as light, ligands and membrane potential. While synthetic ion transport systems, especially those with gating mechanisms, are rare, they have garnered significant attention due to their potential applications in targeted therapeutics as anticancer agents or to treat channelopathies. In this work, we report stimuli-responsive anion transporters based on dynamic hydrogen bonding interactions of hydroxyl-functionalised hydrazone anionophores. Caging of the hydroxyl groups with moities that are responsive to light and H₂S locks the hydrazone protons through intramolecular hydrogen bonding, rendering them unavailable for anion binding and transport. Upon decaging with light or H₂S, the hydrogen bonding pattern is reversed, rendering the hydrazone protons available for anion binding, and leading to efficient switch-on of ion transport across the lipid bilayer membrane.

中文翻译：

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利用笼式腙基阴离子载体的刺激反应性阴离子转运


自然产生的离子通道和泵促进了跨生物膜的离子传输，在生物过程中起着至关重要的作用。门控是这些系统的一个重要方面，其中转运受一系列外部刺激（如光、配体和膜电位）的调节。虽然合成离子转运系统，尤其是那些具有门控机制的系统，很少见，但由于它们在靶向治疗中作为抗癌剂或治疗离子通道病的潜在应用，它们已经引起了极大的关注。在这项工作中，我们报道了基于羟基官能化腙阴离子载体的动态氢键相互作用的刺激响应阴离子转运蛋白。用对光和 H₂S 有反应的分子将羟基笼在笼子里，通过分子内氢键锁定腙质子，使它们无法进行阴离子结合和运输。用光或 H₂S 去壳后，氢键模式发生反转，使腙质子可用于阴离子结合，并导致离子跨脂质双层膜的有效传输开启。