Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to identify new therapies and therapeutic combinations that achieve durable responses in most patients. Further advances in cancer therapy will rely, in part, on the development of targeted therapeutics matched with the genetic and molecular characteristics of cancer. The Cancer Dependency Map (DepMap) is a large-scale data repository and research platform, aiming to systematically reveal the landscape of cancer vulnerabilities in thousands of genetically and molecularly annotated cancer models. DepMap is used routinely by cancer researchers and translational scientists and has facilitated the identification of several novel and selective therapeutic strategies for multiple cancer types that are being tested in the clinic. However, it is also clear that the current version of DepMap is not yet comprehensive. In this Perspective, we review (1) the impact and current uses of DepMap, (2) the opportunities to enhance DepMap to overcome its current limitations, and (3) the ongoing efforts to further improve and expand DepMap.

尽管在过去十年中取得了巨大进步，但癌症的复杂性和异质性使寻找可在大多数患者中实现持久反应的新疗法和治疗组合的努力变得复杂。癌症治疗的进一步发展将部分依赖于与癌症的遗传和分子特征相匹配的靶向疗法的开发。癌症依赖图 （DepMap） 是一个大型数据存储库和研究平台，旨在系统地揭示数千个遗传和分子注释的癌症模型中的癌症脆弱性景观。DepMap 被癌症研究人员和转化科学家常规使用，并有助于确定几种新型和选择性治疗策略，这些策略适用于临床上正在测试的多种癌症类型。但是，很明显，当前版本的 DepMap 还不够全面。在这个观点中，我们回顾了 （1） DepMap 的影响和当前用途，（2） 增强 DepMap 以克服其当前限制的机会，以及 （3） 进一步改进和扩展 DepMap 的持续努力。