Among patients with axial spondyloarthritis (axSpA), persistent pain remains a critical unmet need. In this review, we discuss the prevalence of chronic pain and fibromyalgia in patients with axSpA and examine the existing knowledge on the pathophysiology of chronic pain in SpA, osteoarthritis, and rheumatoid arthritis. Finally, we discuss the specific unmet needs that must be addressed to improve long-term outcomes in axSpA, specifically those that will improve chronic pain in this patient population.

中文翻译：

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脊柱关节炎未满足的需求：了解和管理慢性疼痛。


在中轴型脊柱关节炎 （axSpA） 患者中，持续性疼痛仍然是一个关键的未满足需求。在这篇综述中，我们讨论了 axSpA 患者慢性疼痛和纤维肌痛的患病率，并研究了关于 SpA 慢性疼痛、骨关节炎和类风湿性关节炎的病理生理学的现有知识。最后，我们讨论了为改善 axSpA 的长期结果而必须解决的特定未满足需求，特别是那些将改善该患者群体慢性疼痛的需求。