Cytokines are important regulators of immune responses, making them attractive targets for autoimmune diseases and cancer therapeutics. Yet, the significance of cytokine glycosylation remains underestimated. Many cytokines carry N- and O-glycans and some even undergo C-mannosylation. Recombinant cytokines produced in heterologous host cells may lack glycans or exhibit a different glycosylation pattern such as varying levels of galactosylation, sialylation, fucosylation or xylose addition compared to their human counterparts, potentially impacting critical immune interactions.

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糖基化对用于医疗用途的选定细胞因子及其衍生物开发的影响


细胞因子是免疫反应的重要调节因子，使其成为自身免疫性疾病和癌症治疗的有吸引力的靶标。然而，细胞因子糖基化的重要性仍然被低估。许多细胞因子携带 N-和 O-糖，有些甚至发生 C-甘露糖基化。异源宿主细胞中产生的重组细胞因子可能缺乏聚糖或表现出不同的糖基化模式，例如与人类细胞相比，半乳糖基化、唾液酸化、岩藻糖基化或木糖添加水平不同，从而可能影响关键的免疫相互作用。