Effects of solvent quality on block copolymer (BCP) self-assembly in flow are investigated. Stable kinetically trapped nanoaggregates are created using a continuous flow technique with turbulent mixing under systematically changing THF/water ratios. To elucidate particles morphologies, small angle neutron scattering (SANS) is used as an online analytical method. At high organic solvent contents, elongated particles are observed while at low contents shorter particles are formed. The method can hence be used in a versatile way to control particle morphologies without changing the BCP block lengths used for self-assembly. This offers a more efficient and flexible approach in drug delivery and biomedical applications where particle morphologies directly influence the cell uptake capabilities and reduces the need to resynthesize BCPs with varying block lengths to control size and morphology.

中文翻译：

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连续流块共聚物自组装中的溶剂质量形状控制


研究了溶剂质量对嵌段共聚物 （BCP） 在流动中自组装的影响。在系统变化的 THF/水比下，使用连续流技术和湍流混合产生稳定的动力学捕获纳米聚集体。为了阐明颗粒形态，使用小角中子散射 （SANS） 作为在线分析方法。在有机溶剂含量高时，观察到细长的颗粒，而在低含量时，会形成较短的颗粒。因此，该方法可以以多种方式用于控制颗粒形态，而无需改变用于自组装的 BCP 块长度。这在颗粒形态直接影响细胞摄取能力的药物递送和生物医学应用中提供了一种更高效、更灵活的方法，并减少了重新合成具有不同模块长度的 BCP 以控制大小和形态的需要。