BACKGROUND Drinking water at US Marine Corps Base Camp Lejeune, North Carolina, was contaminated with trichloroethylene and other industrial solvents from 1953 to 1985. METHODS A cohort cancer incidence study was conducted of Marines/Navy personnel who began service and were stationed at Camp Lejeune (N=154,821) or Camp Pendleton, California (N=163,484) between 1975 and 1985 and civilian workers employed at Camp Lejeune (N=6,494) or Camp Pendleton (N=5,797) between October 1972 and December 1985. Camp Pendleton's drinking water was not contaminated with industrial solvents. Individual-level information on primary invasive cancers and in situ bladder cancer diagnosed between 1996 and 2017 was obtained from 54 US cancer registries. Proportional hazards regression was used to calculate adjusted hazard ratios (aHRs) comparing cancer incidence between the Camp Lejeune and Camp Pendleton cohorts, adjusted for sex, race, education, and rank (or blue-collar work), with age as the time variable. Precision of aHRs was evaluated using the 95% confidence interval (CI) ratio (CIR). RESULTS Cancers among Camp Lejeune Marines/Navy personnel and civilian workers totaled 12,083 and 1,563, respectively. Cancers among Camp Pendleton Marines/Navy personnel and civilian workers totaled 12,144 and 1,416, respectively. Compared with Camp Pendleton, Camp Lejeune Marines/Navy personnel had aHRs ≥1.20 with CIRs ≤3 for all myeloid cancers (HR=1.24; 95% CI: 1.03, 1.49), acute myeloid leukemia (HR=1.38; 95% CI: 1.03, 1.85), myelodysplastic and myeloproliferative syndromes (HR=1.68; 95% CI: 1.07, 2.62), polycythemia vera (HR=1.41; 95% CI: 0.94, 2.11), and cancers of the esophagus (HR=1.27; 95% CI: 1.03, 1.56), larynx (HR=1.21; 95% CI: 0.98, 1.50), soft tissue (HR=1.21; 95% CI: 0.92, 1.59), and thyroid (HR=1.22; 95% CI: 1.03, 1.45). Lymphoma subtypes mantle cell and marginal zone B-cell and lung cancer subtypes adenocarcinoma and non-small cell lung cancer also had aHRs ≥1.20 with CIRs ≤3. Compared with Camp Pendleton, Camp Lejeune civilian workers had aHRs ≥1.20 with CIRs ≤3 for all myeloid cancers (HR=1.40; 95% CI: 0.83, 2.36), squamous cell lung cancer (HR=1.63; 95% CI: 1.10, 2.41), and female breast (HR=1.21; 95% CI: 0.97, 1.52) and ductal cancer (HR=1.32; 95% CI: 1.02, 1.71). CONCLUSION Increased risks of several cancers were observed among Marines/Navy personnel and civilian workers exposed to contaminated drinking water at Camp Lejeune compared with Camp Pendleton. https://doi.org/10.1289/EHP14966.

中文翻译：

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美国海军陆战队大本营 Lejeune 饮用水中暴露于工业溶剂的海军陆战队和海军人员以及文职人员的癌症发病率：一项队列研究。


背景 1953 年至 1985 年，北卡罗来纳州美国海军陆战队大本营的饮用水受到三氯乙烯和其他工业溶剂的污染。方法 对 1975 年至 1985 年间开始服役并驻扎在加利福尼亚州勒热恩营 （N=154,821） 或彭德尔顿营 （N=163,484） 的海军陆战队/海军人员以及 1972 年 10 月至 1985 年 12 月期间在勒热恩营 （N=6,494） 或彭德尔顿营 （N=5,797） 雇用的文职人员进行了队列癌症发病率研究。彭德尔顿营的饮用水没有受到工业溶剂的污染。从 54 个美国癌症登记处获得了 1996 年至 2017 年诊断的原发性浸润性癌和原位膀胱癌的个体层面信息。比例风险回归用于计算调整后的风险比 （aHR），比较 Camp Lejeune 和 Camp Pendleton 队列之间的癌症发病率，根据性别、种族、教育和等级（或蓝领工作）进行调整，以年龄为时间变量。使用 95% 置信区间 （CI） 比 （CIR） 评估 aHR 的精度。结果 Camp Lejeune 海军陆战队/海军人员和文职人员的癌症总数分别为 12,083 例和 1,563 例。彭德尔顿营海军陆战队/海军人员和文职人员的癌症总数分别为 12,144 人和 1,416 人。与彭德尔顿营相比，勒热纳营海军陆战队/海军人员的 aHR ≥1.20，CIRs ≤3，适用于所有骨髓癌（HR=1.24;95% CI：1.03,1.49）、急性髓系白血病（HR=1.38;95% CI：1.03,1.85）、骨髓增生异常和骨髓增生综合征（HR=1.68;95% CI：1.07,2.62）、真性红细胞增多症（HR=1.41;95% CI：0.94,2.11）和食管癌（HR=1.27;95% CI： 1.03,1.56）、喉部（HR=1.21;95% CI：0.98,1.50）、软组织（HR=1.21;95% CI：0.92,1.59） 和甲状腺 （HR=1.22;95% CI： 1.03， 1.45）。淋巴瘤亚型、套细胞和边缘区 B 细胞和肺癌亚型、腺癌和非小细胞肺癌的 aHR 也≥1.20，CIRs ≤3。与彭德尔顿营相比，勒热纳营文职人员的 aHR ≥1.20，所有髓系癌（HR=1.40;95% CI：0.83,2.36）、鳞状细胞肺癌（HR=1.63;95% CI：1.10,2.41）和女性乳腺癌（HR=1.21;95% CI：0.97,1.52）和导管癌（HR=1.32;95% CI：1.02,1.71）的 CIRs ≤3。结论 与彭德尔顿营相比，在 Lejeune 营暴露于受污染饮用水的海军陆战队/海军人员和文职人员中观察到患多种癌症的风险增加。https://doi.org/10.1289/EHP14966。