DNA variants arising in the genome of cancer cells are a major cause of therapy failure, but for most variants, their effects on drug response are unknown. Base-editing screens provide a systematic approach to uncover the functions of cancer variants at scale, which might help to inform the use of precision cancer therapies.

中文翻译：

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绘制癌症中的耐药性变异，一次一个碱基


癌细胞基因组中出现的 DNA 变异是治疗失败的主要原因，但对于大多数变异，它们对药物反应的影响尚不清楚。碱基编辑筛选提供了一种系统的方法，可以大规模揭示癌症变异的功能，这可能有助于为精准癌症疗法的使用提供信息。