The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine healthcare. Meticulously building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external stimuli. However, realistic mimesis, both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities, remains a challenging yet vital need for simplifying the design of flexible logic circuits. Herein, we construct an artificial epidermal device by in situ growing Cu₃(HHTP)₂ particles onto the hollow spherical Ti₃C₂T_x surface, aiming to concurrently emulate the spinous and granular layers of the skin’s epidermis. The bionic Ti₃C₂T_x@Cu₃(HHTP)₂ exhibits independent NO₂ and pressure response, as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message communication. Ultimately, a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed circuits. This system can assess risk factors related with asthmatic, such as stimulation of external NO₂ gas, abnormal expiratory behavior and exertion degrees of fingers, achieving a recognition accuracy of 97.6% as assisted by a machine learning algorithm. Our work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

新兴的柔性和智能电子技术极大地促进了远程医疗医疗保健中生理信息的无创和及时跟踪。精心构建对仿生敏感的部分对于设计具有高级认知功能的高效电子皮肤以多元化捕捉外部刺激至关重要。然而，无论是在皮肤的三维互锁分层结构和同步编码多刺激信息能力中，逼真的模仿仍然是简化柔性逻辑电路设计的一个具有挑战性但至关重要的需求。在此，我们通过在空心球形 Ti₃C₂T_x 表面上原位生长 Cu₃（HHTP）₂ 颗粒来构建人工表皮装置，旨在同时模拟皮肤表皮的棘层和颗粒层。仿生 Ti₃C₂T_x@Cu₃（HHTP）₂ 表现出独立的 NO₂ 和压力响应，以及声学特征感知和摩斯电码加密消息通信等新功能。最终，通过将双模传感器集成到柔性印刷电路中，自主开发了带有移动应用终端的可穿戴报警系统。该系统可以评估与哮喘相关的危险因素，例如外部 NO₂ 气体的刺激、异常的呼气行为和手指的用力程度，在机器学习算法的辅助下达到 97.6% 的识别准确率。我们的工作为开发智能多功能医疗设备提供了一个可行的例程，用于新兴的变革性远程医疗诊断。