Opioids are the most common antinociceptive drugs, but long-term administration causes serious adverse side effects. Gelsemium elegans Benth. is traditionally used as an analgesic agent and mainly contains indole alkaloids with structures different from those in common opioids, indicating distinct pharmacological properties. This work aims to find a new analgesic from Gelsemium elegans Benth. and evaluate it in vitro and in vivo.

中文翻译：

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Dihydrokoumine 是一种从传统中药中分离出来的副作用减少的双靶点镇痛药


阿片类药物是最常见的抗伤害性药物，但长期给药会引起严重的不良副作用。Gelsemium elegans Benth.传统上用作镇痛剂，主要含有吲哚类生物碱，其结构与普通阿片类药物不同，表现出不同的药理学特性。这项工作旨在从 Gelsemium elegans Benth 中找到一种新的镇痛药。并在体外和体内对其进行评估。