Pre-clinical data suggest that increased circulating growth differentiation factor 15 (GDF15) is a cause of both anorexia/cachexia syndromes and hyperemesis gravidarum in pregnancy, serious conditions with no highly effective treatment. A phase 2 study of a therapeutic GDF15 monoclonal antibody in the New England Journal of Medicine suggests that effective treatment of anorexia/cachexia in cancer may be approaching.

中文翻译：

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从实验室到床边的 GDF15 研究


临床前数据表明，循环生长分化因子 15 （GDF15） 增加是妊娠期厌食/恶病质综合征和妊娠剧吐的原因，这些严重的情况没有有效的治疗方法。《新英格兰医学杂志》上一项针对治疗性 GDF15 单克隆抗体的 2 期研究表明，癌症厌食症/恶病质的有效治疗可能即将到来。