We computationally designed protein binders for chimeric antigen receptor (CAR) constructs to target the glioblastoma-associated antigens EGFR and CD276. Compared with standard CAR T cells, CAR T cells with the de novo-designed binders showed enhanced proliferation, cytokine release and resistance to exhaustion, as well as superior antitumour effects in vitro and in vivo.

中文翻译：

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提高 CAR T 细胞抗肿瘤功效的蛋白质结合剂的计算设计


我们计算设计了用于嵌合抗原受体 （CAR） 构建体的蛋白质结合剂，以靶向胶质母细胞瘤相关抗原 EGFR 和 CD276。与标准 CAR T 细胞相比，具有从头设计结合剂的 CAR T 细胞在体外和体内表现出增强的增殖、细胞因子释放和抗耗竭能力，以及卓越的抗肿瘤作用。