Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells,Gut Microbes

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Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells
Gut Microbes ( IF 12.2 ) Pub Date : 2024-10-23 , DOI: 10.1080/19490976.2024.2417729
Nicolas Vitari, Salma Singh, Junyi Tao, Bridget Truitt, Udhghatri Kolli, Richa Jalodia, Kathryn M LaPorte, Yaa Abu, Danielle Antoine, Umakant Sharma, Sabita Roy

IgA binding dictates the composition of the intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic and commensal bacteria differentially bind to IgA with varyin...

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