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An Ultrahigh Affinity DNA Aptamer for Quinine and Its Intrinsic Fluorescence Based Label-Free Detection
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2024-10-23 , DOI: 10.1002/chem.202403435
Meheta Datta 1 , Yunus A Kaiyum 2 , Philip E Johnson 2 , Juewen Liu 1
Affiliation  

An ultrahigh affinity DNA aptamer for quinine was obtained using capture-SELEX, and it did not bind to cocaine. In comparison to the prior MN4 aptamer, the new aptamer has 70-fold better affinity with a different way of binding to quinine.

中文翻译:


奎宁的超高亲和力 DNA 适配子及其基于内源荧光的无标记检测



使用 capture-SELEX 获得奎宁的超高亲和力 DNA 适配体,并且它不与可卡因结合。与之前的 MN4 适配子相比,新的适配子与奎宁的结合方式不同,亲和力提高了 70 倍。
更新日期:2024-10-23
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