INTRODUCTIONPeople with dementia may benefit from psychological therapies for depression or anxiety, but evidence of their effectiveness in atypical dementia is limited.METHODSUsing electronic health‐care records of > 2 million people who attended psychological therapy services in England between 2012 and 2019, we examined pre–post therapy symptom changes and compared therapy outcomes among 523 people with atypical dementia, a matched cohort without dementia, and 1157 people with typical dementia.RESULTSPeople with atypical dementia experienced reductions in depression (Cohen d = −0.92 [−1.05 to −0.79]) and anxiety (d = −0.85 [−0.98 to −0.73]) symptoms. They had similar odds of improvement than people with typical dementia (odds ratio [OR] = 1.07, 95% confidence interval [CI]: 0.85 to 1.34), but lower odds than people living without dementia (OR = 0.70, 95% CI: 0.53 to 0.91). Reasons for discharge were similar between all groups.DISCUSSIONPeople with atypical dementia may benefit from primary care psychological therapies, but further research is needed to explore necessary adaptations.Highlights Talking therapies for depression and anxiety may be beneficial for people with atypical dementia. Being younger and having a lower socioeconomic background are associated with poorer outcomes. Receiving more treatment sessions and shorter waiting times are associated with better outcomes.

中文翻译：

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心理疗法对非典型痴呆抑郁和焦虑的有效性


引言患有痴呆症的人可能受益于抑郁症或焦虑症的心理疗法，但其对非典型痴呆有效性的证据有限。方法利用 2012 年至 2019 年间在英格兰参加心理治疗服务的 > 200 万人的电子医疗保健记录，我们检查了 523 名非典型痴呆患者、一个匹配的无痴呆队列和 1157 名典型痴呆患者的治疗结果。结果非典型痴呆患者的抑郁 （Cohen d = -0.92 [-1.05 至 -0.79]）和焦虑 （d = -0.85 [-0.98 至 -0.73]）症状有所减轻。他们的改善几率与典型痴呆患者相似（比值比 [OR] = 1.07,95% 置信区间 [CI]：0.85 至 1.34），但比无痴呆患者低（OR = 0.70,95% CI：0.53 至 0.91）。所有组之间的出院原因相似。讨论非典型痴呆患者可能受益于初级保健心理治疗，但需要进一步研究以探索必要的适应。亮点 抑郁和焦虑的谈话疗法可能对非典型痴呆患者有益。年轻和具有较低的社会经济背景与较差的结果相关。接受更多的治疗和更短的等待时间与更好的结果相关。