Skin wound healing is a complicated biological process that mainly occurs in response to injury, burns, or diabetic ulcers. It can also be triggered by other conditions such as dermatitis and melanoma-induced skin cancer. Delayed healing or non-healing after skin injury presents an important clinical issue; therefore, further explorations into the occurrence and development of wound healing at the cellular and molecular levels are necessary. Single-cell sequencing (SCS) is used to sequence and analyze the genetic messages of a single cell. Furthermore, SCS can accurately detect cell expression and gene sequences. The use of SCS technology has resulted in the emergence of new concepts pertaining to wound healing, making it an important tool for studying the relevant mechanisms and developing treatment strategies. This article discusses the application value of SCS technology, the effects of the latest research on skin wound healing, and the value of SCS technology in clinical applications. Using SCS to determine potential biomarkers for wound repair will serve to accelerate wound healing, reduce scar formation, optimize drug delivery, and facilitate personalized treatments.

中文翻译：

---

皮肤伤口愈合中的单细胞测序技术


皮肤伤口愈合是一个复杂的生物过程，主要发生在受伤、烧伤或糖尿病溃疡时。它也可能由其他疾病引发，例如皮炎和黑色素瘤引起的皮肤癌。皮肤损伤后愈合延迟或不愈合是一个重要的临床问题;因此，有必要在细胞和分子水平上进一步探索伤口愈合的发生和发展。单细胞测序 （SCS） 用于对单个细胞的遗传信息进行测序和分析。此外，SCS 可以准确检测细胞表达和基因序列。SCS 技术的使用导致了与伤口愈合有关的新概念的出现，使其成为研究相关机制和制定治疗策略的重要工具。本文讨论了 SCS 技术的应用价值、最新研究对皮肤伤口愈合的影响以及 SCS 技术在临床应用中的价值。使用 SCS 确定伤口修复的潜在生物标志物将有助于加速伤口愈合、减少疤痕形成、优化药物输送并促进个性化治疗。