We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C. trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution versus persisting infection before treatment (all P< .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.

中文翻译：

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女性对沙眼衣原体的中和抗体反应及其与衣原体结局的关联


我们评估了一个特征明确的队列中的中和抗体反应，该队列由 60 名女性组成，这些女性在治疗访视和 3 个月随访中观察到不同的沙眼衣原体感染结局。我们发现不同稀释水平的血清中和（抑制沙眼衣原体）的速率不同，并且不同结局的中和抗体滴度不同。自发消退女性在高稀释度 （1：320-1：1280） 血清中的中位中和率显著高于治疗前持续感染的女性 （均 P< .05）。这些发现表明，中和抗体反应可能有助于对衣原体的保护性免疫。