Cancer ranks as the second leading cause of death worldwide, and many researchers have found that early screening and diagnosis greatly reduce cancer-related mortality. The use of circulating tumor markers (CTMs) in cancer diagnostics is well warranted, given the potential for CTMs to provide valuable insights into the occurrence and development of cancer. The past two decades have witnessed remarkable advancements in microfluidics based on surface-enhanced Raman spectroscopy (SERS) in the field of biomedicine. It has become a well-established technology for CTM detection. Throughout this review, recent developments of SERS-based microfluidic technology within the realm of CTM detection, including classification, identification, and capture methods, detection mode, as well as novel strategies and applications, have been highlighted. The purpose is to emphasize the importance of detection methods rooted in SERS-based microfluidic technology in biomedicine, as well as to promote their expansion towards various applications.

中文翻译：

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基于 SERS 的微流控传感器用于灵敏检测循环肿瘤标志物：批判性综述


癌症是全球第二大死亡原因，许多研究人员发现，早期筛查和诊断大大降低了癌症相关死亡率。鉴于 CTM 有可能为癌症的发生和发展提供有价值的见解，因此在癌症诊断中使用循环肿瘤标志物 （CTM） 是有道理的。在过去的二十年里，基于表面增强拉曼光谱 （SERS） 的微流体技术在生物医学领域取得了显著进步。它已成为一种成熟的 CTM 检测技术。在本综述中，重点介绍了基于 SERS 的微流控技术在 CTM 检测领域的最新发展，包括分类、识别和捕获方法、检测模式以及新的策略和应用。目的是强调植根于基于 SERS 的微流控技术在生物医学中的检测方法的重要性，并促进其扩展到各种应用。