<br>一种具有血管形成和胶原蛋白再生功能的可注射透明质酸/硅酸锂钙软组织填充剂,Bioactive Materials

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一种具有血管形成和胶原蛋白再生功能的可注射透明质酸/硅酸锂钙软组织填充剂
Bioactive Materials ( IF 18.0 ) Pub Date : 2024-10-23 , DOI: 10.1016/j.bioactmat.2024.10.014
Jinzhou Huang _{1,

2} , Jianmin Xue _{1,

2} , Jimin Huang _{1,

2} , Xinxin Zhang _{1,

2} , Hongjian Zhang _{1,

2} , Lin Du _{1,

2} , Dong Zhai ₁ , Zhiguang Huan _{1,

2} , Yufang Zhu _{1,

2} , Chengtie Wu _{1,

2}

Affiliation

近年来，胶原蛋白和血管在皮肤增强中的重要性已得到认可。然而，目前的皮肤组织填充剂，例如透明质酸（HA）或基于 HA 的水凝胶，由于其长期支持效果不足和缺乏组织诱导活性，无法满足完美的增强要求。在此，由于硅酸盐生物陶瓷优异的生物学功能，开发了一种含有透明质酸（HA）水凝胶和硅酸锂钙（LCS， Li2Ca4Si4O13）生物陶瓷微球的可注射皮肤填充剂，用于皮肤组织填充剂。HA-LCS 填充剂可以通过小于 36 N 的微小标准医用针头（27 G）轻松注射，并且在体外和体内均显示出良好的生物相容性。此外，HA-LCS 填料释放的生物活性离子显著增强了血管形成相关基因和胶原蛋白相关基因的表达。重要的是，HA-LCS 填充剂不仅刺激成熟血管的再生，还促进了真皮皮肤和填充区域的胶原蛋白分泌。本研究不仅提出了一种可增强血管和胶原蛋白再生的可注射填充剂，还为开发基于硅酸盐生物陶瓷生物活性成分的组织诱导填充剂提供了一种新策略。

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An injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration

The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, e.g. hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li2Ca4Si4O13) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both in vitro and in vivo. Furthermore, the bioactive ions released from HA-LCS fillers significantly enhanced the expression of vascularization-related genes and collagen-related genes. Importantly, the HA-LCS fillers not only stimulated the regeneration of mature blood vessels, but also promoted collagen secretion in dermal skin and filling area. This study not only presented an injectable filler with enhanced regeneration of blood vessels and collagen, but also provided a new strategy for developing tissue-induced fillers based on bioactive components of silicate bioceramics.

更新日期：2024-10-23

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