Late-stage deuteration is a crucial technique in the pharmaceutical industry. Direct aromatic deuteration without the use of directing groups or transition-metal catalysts presents a substantial challenge. Now, through the integration of an interrupted Birch reduction, Liang, Xia, and co-workers have developed a photochemical protocol for the efficient hydrogen isotope exchange to incorporate deuterium into the arenes of pharmaceuticals.

中文翻译：

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照明芳香族氘化


后期氘化是制药行业的一项关键技术。不使用定向基团或过渡金属催化剂的直接芳烃氘化是一项巨大的挑战。现在，通过整合中断的 Birch 还原，Liang、Xia 和同事开发了一种用于高效氢同位素交换的光化学方案，将氘掺入药物的芳烃中。