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Oral-gut microbiome interactions in advanced cirrhosis: characterisation of pathogenic enterotypes and salivatypes, virulence factors and antimicrobial resistance
Journal of Hepatology ( IF 26.8 ) Pub Date : 2024-10-22 , DOI: 10.1016/j.jhep.2024.09.046
Sunjae Lee, Bethlehem Arefaine, Neelu Begum, Marilena Stamouli, Elizabeth Witherden, Merianne Mohamad, Azadeh Harzandi, Ane Zamalloa, Haizhuang Cai, Roger Williams, Mike Curtis, Lindsey A. Edwards, Shilpa Chokshi, Adil Mardinoglu, Gordon Proctor, David Moyes, Mark J. McPhail, Debbie L. Shawcross, Mathias Uhlen, Saeed Shoaie, Vishal C. Patel

Cirrhosis complications are often triggered by bacterial infections with multidrug-resistant organisms. Alterations in the gut and oral microbiome in decompensated cirrhosis (DC) influence clinical outcomes. We interrogated: (i) gut and oral microbiome community structures, (ii) virulence factors (VFs) and antimicrobial resistance genes (ARGs) and (iii) oral-gut microbial overlap in patients with differing cirrhosis severity.

中文翻译:


晚期肝硬化中的口腔-肠道微生物组相互作用:致病性肠道型和唾液型、毒力因子和抗菌素耐药性的表征



肝硬化并发症通常由多重耐药微生物的细菌感染引发。失代偿性肝硬化 (DC) 中肠道和口腔微生物组的改变会影响临床结果。我们询问了:(i) 肠道和口腔微生物组群落结构,(ii) 毒力因子 (VFs) 和抗菌素耐药基因 (ARG) 和 (iii) 不同肝硬化严重程度患者的口腔-肠道微生物重叠。
更新日期:2024-10-22
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