α- and β-Functionalized amines are two classes of important compounds, whose structural units are widely present in approved drugs. The hydrofunctionalization of enamides is the most direct and efficient method for constructing these two types of compounds. Regioselectivity is the focus of this conversion, and is largely influenced by the catalytic mode. Therefore, to selectively synthesize α- or β-functionalized amines, the progress in the catalytic hydrofunctionalization of enamides over the past decade is reviewed, and the catalytic pathways for this process discussed in detail. This account aims to objectively evaluate the effects of various catalytic pathways on the regioselectivity of hydrofunctionalization, to provide a new perspective on the selection of catalytic methods and the design of catalytic pathways for the selective synthesis of α- or β-functionalized amines.

α 和 β 官能化胺是两类重要的化合物，其结构单元广泛存在于已批准的药物中。烯酰胺的氢功能化是构建这两类化合物最直接、最有效的方法。区域选择性是这种转化的重点，并且在很大程度上受催化模式的影响。因此，为了选择性合成α官能团或β官能团化胺，综述了过去十年烯酰胺催化氢功能化的进展，并详细讨论了该过程的催化途径。本文旨在客观评价各种催化途径对氢官能化区域选择性的影响，为选择性合成α或β官能化胺的催化途径的选择和催化途径的设计提供新的视角。