Herein, we present a protocol starting from styrene oxide reacting with o-acylaniline and o-alkenylaniline derivatives to obtain 3,4-disubstituted quinoline and 2-acylquinoline derivatives, respectively, in 32–92% yields under specific conditions. Preliminary research outcomes underscore the versatility of our approach, as exemplified by its scalability for large-scale synthesis, downstream derivatization, and the characteristic properties manifested by the modified molecules.

中文翻译：

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从胺类和环氧化物直接合成 3,4-二取代喹啉和 2-酰基喹啉

在此，我们提出了一种方案，从苯乙烯氧化物与邻酰基苯胺和邻烯基苯胺衍生物反应开始，在特定条件下分别以 32-92% 的产率获得 3,4-二取代的喹啉和 2-酰基喹啉衍生物。初步研究结果强调了我们方法的多功能性，其大规模合成、下游衍生化的可扩展性以及修饰分子所表现出的特征特性就是例证。