Piezoelectric materials, recognized as unique functional materials due to their ability to interconvert mechanical and electrical energy, have demonstrated broad application prospects in the biomedical field. Particularly in cancer therapy, piezoelectric materials serve as sonosensitizers that generate internal electric fields under ultrasonic-induced mechanical force, modulating the migration of electrons and holes, and subsequently triggering surface redox reactions to enhance the efficacy of sonodynamic therapy (SDT). SDT, as an emerging non-invasive treatment modality, showcases distinctive advantages such as high tissue penetration, strong spatiotemporal controllability, and low treatment costs due to the synergistic interaction between ultrasound and sonosensitizers. This review systematically discusses various types of piezoelectric materials, with a focus on the recent research progress, mechanisms of action, and optimization strategies of novel materials like perovskites in the SDT domain. Additionally, the applications of piezoelectric materials in the combined treatment of SDT with other therapies are introduced, and the prospects and potential of these materials in tumor sonodynamic therapy are highlighted. By delving into the fundamental principles of the piezoelectric effect and its mechanistic role in SDT, this review offers new perspectives and insights into the biomedical applications of piezoelectric materials.

中文翻译：

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压电材料在肿瘤声动力治疗中的应用进展


压电材料因其能够相互转换机械能和电能而被公认为独特的功能材料，在生物医学领域显示出广阔的应用前景。特别是在癌症治疗中，压电材料用作声敏剂，在超声波感应机械力下产生内部电场，调节电子和空穴的迁移，随后触发表面氧化还原反应，以增强声动力疗法 （SDT） 的疗效。SDT 作为一种新兴的无创治疗方式，由于超声与超声增敏剂之间的协同作用，表现出组织渗透率高、时空可控性强、治疗成本低等独特优势。本文系统讨论了各种类型的压电材料，重点介绍了钙钛矿等新型材料在 SDT 领域的最新研究进展、作用机制和优化策略。此外，介绍了压电材料在 SDT 与其他疗法联合治疗中的应用，并强调了这些材料在肿瘤声动力学治疗中的前景和潜力。通过深入研究压电效应的基本原理及其在 SDT 中的机理作用，本文为压电材料的生物医学应用提供了新的视角和见解。