ObjectiveThe present trial evaluated the first‐time application of autogenous demineralized dentin graft with injectable platelet‐rich fibrin (ADDG + i‐PRF) versus autogenous demineralized dentin graft (ADDG), in alveolar ridge preservation (ARP) in the maxillary aesthetic zone.Material and MethodsTwenty‐two maxillary (n = 22) non‐molar teeth indicated for extraction were randomized into two groups (n = 11/group). Extracted teeth were prepared into ADDG, implanted into extraction sockets with or without i‐PRF amalgamation and covered by collagen sponge. Cone‐beam computed tomography scans at baseline and 6 months were compared to assess ridge‐dimensional changes. Keratinized tissue width, patient satisfaction, pain score and chair time were recorded. In the course of dental implant placements at 6 months, bone core biopsies of engrafted sites were obtained and analysed histomorphometrically.ResultsReduction in ridge width was 1.71 ± 1.08 and 1.8 ± 1.35 mm, while reduction in ridge height was 1.11 ± 0.76 and 1.8 ± 0.96 mm for ADDG + i‐PRF and ADDG, respectively (p > 0.05). Significant differences in keratinized tissue width reduction were notable between ADDG + i‐PRF and ADDG (0.12 ± 0.34 and 0.58 ± 0.34 mm respectively; p = 0.008). Postoperative pain scores were significantly lower in ADDG + i‐PRF (p = 0.012). All patients in the two groups were satisfied with no differences in chair time (p > 0.05). No differences in total percentage area of newly formed bone, soft tissue or graft particles were observed between the groups (p > 0.05).ConclusionsADDG alone or in combination with i‐PRF yields similar results regarding ARP clinically, quality of the formed osseous tissues, as well as patients' satisfaction. Yet, the addition of i‐PRF to ADDG tends to preserve the keratinized tissue and lessen postoperative pain.

中文翻译：

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可注射的富含血小板的纤维蛋白与自体脱矿质牙本质相结合是否能增强牙槽嵴的保留？一项随机对照试验


目的本试验评估了自体脱矿牙本质移植物与注射用富含血小板的纤维蛋白 （ADDG + i-PRF） 与自体脱矿质牙本质移植物 （ADDG） 在上颌骨美学区牙槽嵴保留 （ARP） 中的首次应用。材料和方法将 22 颗用于拔除的上颌牙 （n = 22） 非磨牙随机分为两组 （n = 11/组）。将拔出的牙齿制备到 ADDG 中，植入有或没有 i-PRF 汞齐的拔牙窝中，并用胶原蛋白海绵覆盖。比较基线和 6 个月的锥形束计算机断层扫描扫描以评估脊尺寸变化。记录角化组织宽度、患者满意度、疼痛评分和椅子时间。在 6 个月时种植牙的过程中，获得移植部位的骨芯活检并进行组织形态学分析。结果ADDG + i-PRF 和 ADDG 的脊宽减少 1.71 ± 1.08 和 1.8 ± 1.35 mm，而脊高度减少 1.11 ± 0.76 和 1.8 ± 0.96 mm，分别为 1.76 和 1.8 0.96 mm（p > 0.05）。ADDG + i-PRF 和 ADDG 之间角化组织宽度减少的显着差异显着 （分别为 0.12 ± 0.34 和 0.58 ± 0.34 mm;p = 0.008）。ADDG + i-PRF 的术后疼痛评分显着降低 （p = 0.012）。两组患者均对椅旁时间无差异感到满意 （p > 0.05）。两组之间未观察到新形成的骨、软组织或移植物颗粒的总百分比面积差异 （p > 0.05）。结论ADDG 单独或联合 i-PRF 在 ARP 临床、形成的骨组织质量以及患者满意度方面产生相似的结果。 然而，在 ADDG 中添加 i-PRF 往往会保留角化组织并减轻术后疼痛。