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Properties governing small-molecule partitioning into biomolecular condensates
Nature Chemistry ( IF 19.2 ) Pub Date : 2024-10-22 , DOI: 10.1038/s41557-024-01655-1
Bappaditya Chandra, Swarnendu Tripathi, Richard Kriwacki

Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a diverse panel of condensates.

中文翻译:


控制小分子分配到生物分子凝聚物中的特性



被称为生物分子凝聚物的无膜细胞组装体——不同的生物聚合物分配到其中——介导着无数的生物过程。现在的一项研究表明,物理化学特征,而不是特定的立体化学,会影响小分子是富集在各种凝聚物中还是从中排除。
更新日期:2024-10-22
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