Altered redox metabolism is one of the hallmarks of tumor cells, which not only contributes to tumor proliferation, metastasis, and immune evasion, but also has great relevance to therapeutic resistance. Therefore, regulation of redox metabolism of tumor cells has been proposed as an attractive therapeutic strategy to inhibit tumor growth and reverse therapeutic resistance. In this respect, nanomedicines have exhibited significant therapeutic advantages as intensively reported in recent studies. In this review, we would like to summarize the latest advances in nanomaterial-assisted strategies for redox metabolic regulation therapy, with a focus on the regulation of redox metabolism-related metabolite levels, enzyme activity, and signaling pathways. In the end, future expectations and challenges of such emerging strategies have been discussed, hoping to enlighten and promote their further development for meeting the various demands of advanced cancer therapies. It is highly expected that these therapeutic strategies based on redox metabolism regulation will play a more important role in the field of nanomedicine.

中文翻译：

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基于纳米材料的氧化还原代谢调节以增强癌症治疗


改变的氧化还原代谢是肿瘤细胞的标志之一，它不仅有助于肿瘤增殖、转移和免疫逃逸，而且与治疗耐药性密切相关。因此，调节肿瘤细胞的氧化还原代谢已被提议作为抑制肿瘤生长和逆转治疗耐药性的有吸引力的治疗策略。在这方面，纳米药物表现出显着的治疗优势，正如最近的研究中所密集报道的那样。在这篇综述中，我们想总结纳米材料辅助氧化还原代谢调控治疗策略的最新进展，重点是氧化还原代谢相关代谢物水平、酶活性和信号通路的调节。最后，讨论了此类新兴策略的未来预期和挑战，希望能启发和促进其进一步发展，以满足先进癌症治疗的各种需求。这些基于氧化还原代谢调控的治疗策略将在纳米医学领域发挥更重要的作用，值得期待。