The development of flow processes for metal-ligand self-assembly and ring-closing metathesis has facilitated the efficient and scalable preparation of iron(II) pentafoil knot and Star of David [2]catenane. Use of a flow reactor also enables the formation of the otherwise inaccessible coordinatively labile zinc(II) pentameric helicate, leading to an efficient two-step synthesis of the zinc(II) pentafoil knot. As the first example of topology-synthesis in flow, our work demonstrates that the metal-ligand self-assembly can be readily adapted to flow techniques, even for labile complexes that are difficult to prepare in batches. The method is well-positioned for expansion to other topological complexes made from the metal template approach. Transitioning from laboratory batch synthesis to efficient large-scale production using continuous flow reactors not only paves the way for new applications of flow synthesis in chemical topology but also enhances the accessibility of these “hard-to-make” entangled moieties, thereby opening avenues for exploring their applications in various fields.

中文翻译：

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大卫之星 [2] 链烷和五箔结的高效流动合成


金属配体自组装和闭环复分解的流动工艺的发展促进了铁 （II） 五箔结和大卫之星 [2] 链烷的高效和可扩展制备。使用流动反应器还可以形成原本无法接近的协调不稳定的锌 （II） 五聚体螺旋体，从而有效地两步合成锌 （II） 五聚体结。作为流动中拓扑合成的第一个例子，我们的工作表明，金属配体自组装可以很容易地适应流动技术，即使对于难以批量制备的不稳定复合物也是如此。该方法非常适合扩展到由金属模板方法制成的其他拓扑复合物。从实验室间歇合成过渡到使用连续流反应器的高效大规模生产，不仅为流动合成在化学拓扑学中的新应用铺平了道路，而且还增强了这些“难以制造”的纠缠部分的可及性，从而为探索它们在各个领域的应用开辟了途径。