Due to their low activation energy barriers, small strained carbocyclic systems have always been fascinating building blocks in organic chemistry. Among them, BCBs, as the smallest bicyclic carbocycles, exhibit a molecular structure, bond angles, and orbital hybridization significantly different from those of strain-free hydrocarbons, resulting in unique reactivity. In recent years, Lewis acid-catalyzed strain-release cycloaddition reactions have made BCBs powerful synthetic tools, utilized in various laboratories to expand into other ring systems. This review primarily focuses on the latest developments in Lewis acid-catalyzed strain-release cycloaddition reactions of BCBs, highlighting the applications and limitations of this catalytic system in different types of cycloaddition reactions, providing professionals and non-professionals in the field with valuable insights and new inspiration.

中文翻译：

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Lewis 酸催化的双环 [1.1.0] 丁烷 （BCB） 菌株释放环加成反应的最新策略


由于其低活化能势垒，小应变碳环系统一直是有机化学中令人着迷的组成部分。其中，BCBs 作为最小的双环碳环，表现出与无应变碳氢化合物明显不同的分子结构、键角和轨道杂交，从而产生独特的反应性。近年来，Lewis 酸催化的菌株释放环加成反应使 BCB 成为强大的合成工具，在各种实验室中用于扩展到其他环系统。本文主要综述了 Lewis 酸催化的 BCBs 菌株释放环加成反应的最新进展，重点介绍了该催化体系在不同类型的环加成反应中的应用和局限性，为该领域的专业人士和非专业人士提供了有价值的见解和新的启发。