It was well known that rare earth elements (REE) oxides nanoparticles could inhibit tumor growth and promote osteogenesis. In this works, four WE43 magnesium alloys (AO-10, AO-30, AO-1h and AO-2h) containing different REE oxides nanoparticles were prepared by anodic oxidation plus heat treatment. The REE oxides nanoparticles on AO-10, AO-30, AO-1h and AO-2h surface were Gd2O3 and Nd2O3, (Gd0.745Y1.255)O3 and Nd2O3, (Gd0.18Y1.82)O3 and Gd2O3 as well as Y2O3 and Gd2O3, respectively. Subsequently, the bioactivity, antitumor property and osteogenic property of all materials in vitro and in vivo were studied, and their antitumor property, bioactivity and osteogenic property were all AO-2h > AO-1h > AO-30 > AO-10. The degradation behaviors of materials in vitro and vivo were further investigated, and the corrosion resistance of materials was AO-10 > AO-30 > AO-1h > AO-2h. AO-2h released the most H2 and produced the highest pH value in all materials during degradation. The results showed that the effects of different REE oxides nanoparticles on corrosion resistance, biactivity, osteogenic property and antitumor property of materials were different completely. In all materials, AO-30 had moderate inhibition of MG63 and 143B cells in vitro, and it could inhibit the growth of bone tumor in mice in vivo. Then, the osteogenic property of AO-30 was moderate. It could promote the adhesion and proliferation of MC3T3-E1 cells. Again, the corrosion resistance of AO-30 was relatively excellent. It release few H2, Mg2+ and REE. The REE levels in normal tissues were relatively low, whose effects was negligible. Hence, AO-30 was the most suitable material for anti-bone tumor in all materials.

中文翻译：

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在 WE43 镁合金表面形成的稀土氧化物纳米颗粒经阳极氧化加热处理用于抗骨肿瘤


众所周知，稀土元素 （REE） 氧化物纳米颗粒可以抑制肿瘤生长并促进成骨。在本工作中，通过阳极氧化加热处理制备了四种含有不同稀土氧化物纳米颗粒的 WE43 镁合金 （AO-10、AO-30、AO-1h 和 AO-2h）。AO-10、AO-30、AO-1h 和 AO-2h 表面的稀土氧化物纳米颗粒分别为 Gd2O3 和 Nd2O3、（Gd0.745Y1.255）O3 和 Nd2O3、（Gd0.18Y1.82）O3 和 Gd2O3 以及 Y2O3 和 Gd2O3。随后，研究了所有材料在体外和体内的生物活性、抗肿瘤性能和成骨性，其抗肿瘤性、生物活性和成骨性均为 AO-2h > AO-1h > AO-30 > AO-10。进一步研究了材料在体外和体内的降解行为，材料的耐腐蚀性为 AO-10 > AO-30 > AO-1h > AO-2h。AO-2h 在降解过程中释放的 H2 最多，产生的 pH 值在所有材料中最高。结果表明，不同稀土氧化物纳米颗粒对材料的耐腐蚀性、双活性、成骨性能和抗肿瘤性能的影响完全不同。在所有材料中，AO-30 在体外对 MG63 和 143B 细胞具有中度抑制作用，在体内可抑制小鼠骨肿瘤的生长。然后，AO-30 的成骨特性中等。它可以促进 MC3T3-E1 细胞的粘附和增殖。同样，AO-30 的耐腐蚀性相对较好。它释放很少的 H2、Mg2+ 和 REE。正常组织中的 REE 水平相对较低，其影响可以忽略不计。因此，AO-30 是所有材料中最适合抗骨肿瘤的材料。