Disrupted circadian or 24-h rhythms are among the most common early findings in a wide range of neurodegenerative disorders. Once thought to be a mere consequence of the disease process, increasing evidence points toward a causal or contributory role of the circadian clock in neurodegenerative disease. Circadian clocks control many aspects of cellular biochemistry, including stress pathways implicated in neuronal survival and death. Given the dearth of disease-modifying therapies for these increasingly prevalent disorders, this understanding may lead to breakthroughs in the development of new treatments. In this review, we provide a background on circadian clocks and focus on some potential mechanisms that may be pivotal in neurodegeneration.

中文翻译：

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生物钟、日常压力和神经退行性疾病


昼夜节律或 24 小时节律紊乱是各种神经退行性疾病中最常见的早期发现之一。曾经被认为仅仅是疾病过程的结果，越来越多的证据表明生物钟在神经退行性疾病中起因果或促成作用。生物钟控制细胞生物化学的许多方面，包括与神经元存活和死亡有关的应激途径。鉴于这些日益普遍的疾病缺乏疾病修饰疗法，这种理解可能会导致新疗法开发的突破。在这篇综述中，我们提供了生物钟的背景，并重点介绍了一些可能在神经退行性变中起关键作用的潜在机制。