In recent years, significant strides in both conceptual understanding and technological capabilities have bolstered our comprehension of the factors underpinning cancer initiation and progression. While substantial insights have unraveled the molecular mechanisms driving carcinogenesis, there has been an overshadowing of the critical contribution made by epigenetic pathways, which works in concert with genetics. Mounting evidence demonstrates cancer as a complex interplay between genetics and epigenetics. Notably, epigenetic elements play a pivotal role in governing alternative pre-mRNA splicing, a primary contributor to protein diversity. In this review, we have provided detailed insights into the bidirectional communication between epigenetic modifiers and alternative splicing, providing examples of specific genes and isoforms affected. Notably, succinct discussion on targeting epigenetic regulators and the potential of the emerging field of epigenome editing to modulate splicing patterns is also presented. In summary, this review offers valuable insights into the intricate interplay between epigenetics and alternative splicing in cancer, paving the way for novel approaches to understanding and targeting this critical process.

中文翻译：

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癌症中的表观遗传学和选择性剪接：老敌人，新视角。


近年来，概念理解和技术能力的重大进步加强了我们对癌症发生和发展因素的理解。虽然实质性的见解已经揭示了驱动致癌作用的分子机制，但表观遗传途径的关键贡献被掩盖了，它与遗传学协同工作。越来越多的证据表明，癌症是遗传学和表观遗传学之间复杂的相互作用。值得注意的是，表观遗传学元件在控制选择性前 mRNA 剪接中起着关键作用，这是蛋白质多样性的主要贡献者。在这篇综述中，我们对表观遗传修饰因子和选择性剪接之间的双向通讯提供了详细的见解，提供了受影响的特定基因和亚型的示例。值得注意的是，还简要讨论了靶向表观遗传调节因子以及新兴的表观基因组编辑领域调节剪接模式的潜力。总之，这篇综述为癌症中表观遗传学和选择性剪接之间错综复杂的相互作用提供了有价值的见解，为理解和靶向这一关键过程的新方法铺平了道路。