Establishing, maintaining, and removing histone post-translational modifications associated with heterochromatin is critical for shaping genomic structure and function as a cell navigates different stages of development, activity, and disease. Dynamic regulation of the repressive chromatin landscape has been documented in several key cell states - germline cells, activated immune cells, actively replicating, and quiescent cells - with notable variations in underlying mechanisms. Here, we discuss the role of cell states of these diverse contexts in directing and maintaining observed chromatin landscapes. These investigations reveal heterochromatin architectures that are highly responsive to the functional context of a cell's existence and, in turn, their contribution to the cell's stable identity.

中文翻译：

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细胞状态对异染色质动力学的影响。


建立、维持和去除与异染色质相关的组蛋白翻译后修饰对于塑造基因组结构和功能至关重要，因为细胞会经历发育、活动和疾病的不同阶段。抑制染色质景观的动态调节已在几种关键细胞状态（种系细胞、活化免疫细胞、主动复制细胞和静止细胞）中得到证实，潜在机制存在显着变化。在这里，我们讨论了这些不同背景的细胞状态在指导和维持观察到的染色质景观方面的作用。这些研究揭示了异染色质结构，这些结构对细胞存在的功能环境高度敏感，进而它们对细胞稳定身份的贡献。