We studied SARS-CoV-2 binding and neutralizing antibody titers among previously infected persons in the United States over time. We assayed SARS-CoV-2 spike protein receptor-binding domain and neutralizing antibody titers for a convenience sample of residual clinical serum specimens that had evidence of prior SARS-CoV-2 infection gathered during January 2021–February 2022. We correlated titers and examined them by age group (<18, 18–49, 50–64, and >65 years) across 4 different SARS-CoV-2 variant epochs. Among selected specimens, 30,967 had binding antibody titers and 744 had neutralizing titers available. Titers in specimens from children and adults correlated. In addition, mean binding antibody titers increased over time for all age groups, and mean neutralization titers increased over time for persons 16–49 and >65 years of age. Incorporating binding and neutralization antibody titers into infectious disease surveillance could provide a clearer picture of overall immunity and help target vaccination campaigns.

我们研究了美国既往感染者随时间推移的 SARS-CoV-2 结合和中和抗体滴度。我们检测了 SARS-CoV-2 刺突蛋白受体结合域和中和抗体滴度，以获得 2021 年 1 月至 2022 年 2 月期间收集的具有先前 SARS-CoV-2 感染证据的残留临床血清标本的便捷样本。我们关联了滴度，并按年龄组（<18、18-49、50-64 和 >65 岁）在 4 个不同的 SARS-CoV-2 变体时期进行了检查。在选定的标本中，30,967 例具有结合抗体滴度，744 例具有可用的中和滴度。儿童和成人标本中的滴度相关。此外，所有年龄组的平均结合抗体滴度随着时间的推移而增加，16-49 岁和 >65 岁的人的平均中和滴度随着时间的推移而增加。将结合和中和抗体滴度纳入传染病监测可以更清楚地了解整体免疫力，并有助于有针对性地开展疫苗接种活动。