Oral human papillomavirus (HPV) is associated with oropharyngeal cancer (OPC). Although OPC incidence is increasing globally, knowledge of oral HPV infection rates is limited. Here we carried out an observational epidemiological analysis of oral HPV incidence in 3,137 men enrolled from the United States, Mexico and Brazil between 2005 and 2009. Individuals were followed for new HPV infection for a median of 57 months. Cumulative incidence and factors associated with acquisition were also assessed. The incidence rate of oral oncogenic HPV was 2.4 per 1,000 person-months, did not vary with age and was constant throughout the study period. Risk of oral HPV acquisition was significantly associated with alcohol consumption, having male sexual partners, more lifetime female sexual partners, more oral sex given and higher educational attainment. These data indicate that men are at risk of acquiring oral HPV throughout their lifetime, suggesting that catch-up vaccination may reduce new infection incidence.

口服人瘤病毒 （HPV） 与口咽癌 （OPC） 有关。尽管 OPC 发病率在全球范围内不断增加，但对口腔 HPV 感染率的了解有限。在这里，我们对 2005 年至 2009 年间从美国、墨西哥和巴西招募的 3,137 名男性的口服 HPV 发病率进行了观察性流行病学分析。个体的新 HPV 感染随访中位时间为 57 个月。还评估了累积发生率和与获得相关的因素。口服致癌 HPV 的发病率为 2.4/1,000 人月，不随年龄变化，在整个研究期间保持不变。口腔 HPV 感染的风险与饮酒、拥有男性性伴侣、终生女性性伴侣更多、次数更多和受教育程度较高显著相关。这些数据表明，男性一生中都有感染口服 HPV 的风险，这表明补种疫苗接种可能会降低新感染的发生率。