The Ventromedial hypothalamic nucleus (VMN) maintains healthy metabolic function through several important roles. Collectively, homeostasis is maintained via intermingled cells within the VMN that raise blood glucose, lower blood glucose, and stimulate energy expenditure when needed. This perspective discusses the defining factors for the VMN cell types that govern distinct functions induced by the VMN, particularly in relation to energy balance and blood glucose levels. Special attention is given to distinct features of VMN cells responsible for these processes. Finally, these topics are reviewed in the context of research funded by the Pathway to Stop Diabetes initiative, highlighting key findings and current unresolved questions for future investigations.

中文翻译：

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肥胖和糖尿病患者腹内侧下丘脑神经元群的功能分离


腹内侧下丘脑核 （VMN） 通过几个重要作用维持健康的代谢功能。总的来说，体内平衡是通过 VMN 内的混合细胞来维持的，这些细胞会在需要时提高血糖、降低血糖并刺激能量消耗。该观点讨论了 VMN 细胞类型的定义因素，这些细胞类型控制着 VMN 诱导的不同功能，特别是与能量平衡和血糖水平有关。特别关注负责这些过程的 VMN 细胞的独特特征。最后，在 Pathway to Stop Diabetes 倡议资助的研究背景下审查了这些主题，突出了关键发现和当前未解决的问题，以供未来调查。