The demand for a cost-effective in-line particle measurement device is high, and the image analysis of particles in flow represents a promising concept to meet these expectations. In this work, we present an in-house developed image analysis flow cell to track particle size distributions in a process stream, including the necessary code and printing files for open-source use. For benchmarking of the flow cell, premade seeded solutions were prepared and analyzed by comparing the results to already applied and commercially available particle measurement devices. Furthermore, the results of six mixed-suspension, mixed-product-removal crystallization experiments were evaluated with the new measurement system.

中文翻译：

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开发 3D 打印流通池，用作在线光学颗粒分析工具


对经济高效的在线颗粒测量设备的需求很高，而流动中颗粒的图像分析代表了满足这些期望的一个很有前途的概念。在这项工作中，我们提出了一个内部开发的图像分析流动池，用于跟踪工艺流中的粒度分布，包括开源使用所需的代码和打印文件。为了对流通池进行基准测试，制备了预制的晶种溶液，并通过将结果与已应用的市售颗粒测量设备进行比较进行分析。此外，使用新的测量系统评估了 6 个混合悬浮、混合产物去除结晶实验的结果。